Common use

Tiotropium Bromide is a specific antagonist of muscarinic receptors with longterm action. It reversibly blocks receptors of M3 type in respiratory track which results in relaxation of smooth muscles of the bronchial tree. High affinity of the receptors and slow release of the inhibitor from the complex with M3 receptor stipulates prolonged local action of Tiovais. Bronholitic effect of the drug results of local action, dose and persisted for at least 24 hours. Effects of Tiotropium Bromide depend on the dose and continues for 24 hours. The medication is used to treat bronchial spasms (wheezing) caused by chronic obstructive pulmonary disease, chronic bronchitis and emphysema.



Dosage and direction

Tiotropium Bromide comes as capsules with powder for inhalations with the HandiHaler inhalation device. Use the medication about the same time each day.



Precautions

Cautiousness is needed in treatment of patients with narrow-angle glaucoma, urination disorders caused by prostatic hypertrophy or obstruction of the bladder neck. Tiovais cannto be used for urgent blockage of a bronchial spasm. Avoid getting of the medication in eyes. Monitoring on a regular basis is needed in the patients with moderate and severe renal failure treated by Tiovais and medications which excreted by the kidneys. Inhaled medications may cause paradoxical bronchospasm and other reactions of such kind. Avoid administration of the medication if you are pregnant or breastfeeding.



Contraindications

Tiotropium Bromide cannot be administered to the patients with hypersensitivity to the medication, atropine and its derivates (ipratropium and oxytropine). Use in adolescents under 18 years of age is not researched.





Possible side effects

Most common side effects include local reactions such as dry mouth, throat pain, coughing, paradoxical bronchospasm. Changes in accommodation if the medication got into the eyes. Allergic reactions (rash, swelling) are possible. In rare were observed cases short heart beat, acute glaucoma, difficulty urination in men with prostatic hypertrophy, constipation.



Drug interactions

Concomitant use of Tiotropium Bromide with other anticholinergetic medications is not recommended.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your doses at about the same time each day to avoid missing a dose.



Overdose

It was not reported about overdose if Tiotropium Bromide was used in therapeutic doses. In case of considerable exceeding of the recommended dose symptoms associated with anticholinergetic properties of the medication are observed: reversible changes in accommodation, dry mouth. Acute poisoning is not likely due to low biological availability of the medication used as inhalations.



Storage

Store at room temperature away from moisture, sunlight, kids and pets in a tight container.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.