Important information about Epivir

Epivir should not be taken together with Combivir, a medication that contains a combination of lamivudine and zidovudine.

Epivir may cause lactic acidosis (the build up of lactic acid in the body).

Symptoms can start slowly and gradually get worse: unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs. Call your doctor at once if you have any of these symptoms, even if they are only mild.

Epivir can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have any of these symptoms while taking this medication: severe pain in your upper stomach spreading to your back, fast heart rate, nausea and vomiting, diarrhea, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Before taking Epivir, tell your doctor if you have kidney disease, liver disease, a history of pancreatitis, or if you have used a medicine similar to Epivir in the past, such as abacavir (Ziagen), didanosine (Videx), stavudine (Zerit), tenofovir (Viread), zalcitabine (Hivid), or zidovudine (Retrovir). If you have hepatitis B you may develop liver symptoms after you stop taking Epivir, even months after stopping. Your doctor may want to check your liver function on a regular basis for several months after you stop using this medication.

Do not miss any scheduled visits.

Epivir tablets and liquid contain a higher dose of lamivudine than Epivir-HBV. Epivir is for treating HIV and Epivir-HBV is for treating hepatitis B. Each time you get a refill of this medication, be sure you have received the correct brand to treat your condition.

Before taking Epivir

You should not take Epivir if you are also taking Combivir (lamivudine/zidovudine), or if you have ever had an allergic reaction to a medicine containing lamivudine, including Combivir, Epzicom, or Trizivir. Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:

�kidney disease;

�liver disease (including hepatitis B);

�a history of pancreatitis; or

�if you have used a medicine similar to Epivir in the past, such as abacavir (Ziagen), didanosine (Videx), stavudine (Zerit), tenofovir (Viread), zalcitabine (Hivid), or zidovudine (Retrovir). If you have any of the conditions listed above, you may need a dose adjustment or special tests to safely take this medication.

Epivir may cause lactic acidosis (the build up of lactic acid in the body). Lactic acidosis symptoms can start slowly and gradually get worse. Symptoms include unusual muscle pain and weakness, trouble breathing, nausea, fast or uneven heart rate, vomiting, stomach pain and numbness or cold feeling in your arms or legs. Call your doctor at once if you have any of these symptoms, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal.

Epivir can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have any of these symptoms while taking this medication: severe pain in your upper stomach spreading to your back, fast heart rate, nausea and vomiting, low fever, diarrhea, loss of appetite, dark urine, clay-colored stools or jaundice (yellowing of the skin or eyes).

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Epivir may also be more likely to cause pancreatitis in a pregnant woman. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant. Your name may need to be listed on an antiviral pregnancy registry when you start using Epivir. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether Epivir had any effect on the baby.

You should not breast-feed while you are using this medication. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.

If you have diabetes, you should know that the liquid forms of Epivir contain 3 to 4 grams of sucrose (sugar) per dose.