How to Use

Estradiol Valerate USP is not recommended for use in patients with the following conditions:

• Unusual vaginal bleeding
• History of heart attack or stroke in the last year
• Allergic to estradiol valerate
• History of blood clots disorder
• Any form of cancer
• If you plan on becoming pregnant

To ensure the safe use of this drug, let the prescribing doctor know:

• If you are breastfeeding a baby
• Of all the medications you are on
• About your medical history (liver disease, thyroid disorder, migraines, epilepsy, gallbladder disease, high or low calcium levels in the blood, uterus removal, jaundice)
• If you are scheduled for surgery or bed rest

Estradiol Valerate USP should be taken exactly as prescribed. The medicine is injected deeply into the upper, outer quadrant of your muscle. Special care should be taken when administering the drug. Use a dry needle and syringe to keep the solution from becoming cloudy. Estrogen should be used at the lowest dose possible.

Before using the medicine, inspect it for discoloration or particulate matter. The solution is colorless to pale yellow.

FDA Pregnancy Classification

Category X

Estradiol Valerate USP can cause harm to an unborn baby and birth defects. Don’t use this drug while pregnant. Estradiol can pass into breast milk and cause harm to a nursing baby.

Storage

Store at room temperature and away from light, heat and moisture. Keep the bottle sealed.

Side Effects

Serious

• Symptoms of a heart attack (chest pressure or pain, pain that spreads to the jaw or shoulder, sweating, nausea)
• Signs of blood clot in the leg (pain, warmth, swelling or redness in the legs)
• Jaundice
• Unusual vaginal bleeding
• Lump in the breast
• Fluid retention (rapid weight gain, swelling)
• High levels of calcium (vomiting, loss of appetite, increased thirst, muscle weakness or pain, confusion, restlessness, constipation)

Common

• Thinning scalp hair
• Breast pain
• Nausea, vomiting, stomach cramps, bloating
• Headache
• Vaginal discharge, or itching
• Changes in menstrual periods

Safety

When using Estradiol Valerate USP, you are advised to watch out for symptoms related to endometrial, breast or ovarian cancer. You will need to self-examine your breasts for any lumps or changes and report any unusual vaginal bleeding to your doctor. Your doctor will check your progress every 3 to 6 months.

Interactions

Estradiol Valerate USP interacts with 230 drugs and 14 diseases.